Maxine's husband has just died of a sudden heart attack while he was on the road with their brand new Peterbilt Truck. Maxine reveals to Charlotte that Nelson's heart attack could not have come at a worse time. They just bought the new rig, and Maxine is left in debt up to her eyeballs.

Trying to help, yet feeling at a loss, Charlotte says, "It's a shame you can't just pick up where Nelson left off." Charlotte, of course does not really mean it, but Maxine suddenly figures… "Why NOT?" And so the adventure begins! And, while they're at it, they will take Nelson's ashes with them, hoping to find just the right place to spread them where he would be most happy.

The two women, assisted by Maxine's loveable yet intensely micromanaging neighbor, Mary Ellen, pack the truck and take off on their first run. They get off to a bad start by taking a wrong turn and creating a major incident in a "NO TRUCK ZONE," but soon feel reassured when they meet "Sugar Daddy" on the CB radio followed by Roy McCoy, a strange little guy with very big feet. Is it true what they say about a man with big feet?

Things get complicated they meet a hooker named Trixie at Rosie Mae's Truck Stop. It seems Trixie knew Nelson quite well and Maxine is not amused. It now becomes painfully apparent that they have found just the right spot for Nelson's ashes. In a roaring fury, Maxine locks herself in the Ladies Room, gives her farewell speech and flushes Nelson down the toilet. After all, he loved the water, the ladies and Rosie Mae's Truck Stop. What could be more perfect?

With Maxine finally reaching "Closure", the two women climb back aboard their shiny new truck and take to the road with the goal of putting their past behind them and looking forward to what lies ahead.

LOOK OUT… Here come the Mother Truckers. "The road" will never be the same again!